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Adeno-associated viruses (AAV) have been widely used for neuronal transduction studies owing to long-term and stable gene expression as well as low immunoreactivity in humans.

Here we report that AAV2-2 transduces CSMN with high efficiency upon direct cortex injection and that transduction efficiencies are similar during presymptomatic and symptomatic stages in h SOD1 transgenic amyotrophic lateral sclerosis (ALS) mice.

After controlling for the study covariates, there was no significant difference in the odds of feeling better (less worried) postchat between IM and text message users.

Feeling better postchat was associated with being younger (≤17 years: AOR 1.42, 95% CI 1.17-1.72; 18-24 years: AOR 1.20, 95% CI 1.02-1.42), being Latino/Hispanic (AOR 1.31, 95% CI 1.10-1.55), reporting that the service was very helpful (AOR 3.47, 95% CI 3.24-4.32), and asking about emergency contraception (AOR 1.35, 95% CI 1.13-1.61).

Thus, in the near future, we will need to deliver the genes of interest to the vulnerable neurons without inducing confounding variables in other neurons and circuitries.

Evidence suggests that technologies such as instant messaging (IM) and text messaging may be effective ways to provide teens and young adults with sexual and reproductive health information.

In September 2010, Planned Parenthood Federation of America launched a text and IM program designed to provide immediate answers to urgent sexual and reproductive health questions from a reliable and confidential source and to link young people to sexual and reproductive health services if needed.

Building effective and long-term treatment strategies requires genetic modulations that are stable and long lasting.

Adeno-associated virus (AAV) offers several significant advantages when compared with other gene delivery systems.

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